Children's Technology Development Fund Awards $1.2M to Hospital Researchers

New Technology Listings

Therapeutics:

Novel Treatment for Polycystic Kidney Disease (PKD)               

        Keywords: Therapeutics, Urology, Animal Model (mouse)
      Lead Investigator: Jordan Kreidberg, MD, PhD

Injectable Therapeutic for Heart Failure       

        Keywords: Therapeutics, Cardiovascular/Cardiology, Regenerative Medicine, Large Molecule
      Lead Investigator: Bernhard Kuhn, MD

Novel Pneumococcal Vaccine with Adjuvant Properties     

        Keywords: Therapeutics, Immunology, Infectious Disease, Pediatric
      Lead Investigator: Richard Malley, MD

Diagnostics:

Test for Developmental Delay or Autism      

        Keywords: Diagnostic/Prognostic, Genetic Disease, Neonatology/Pediatric, Neurology, Biomarker
      Lead Investigator: Bai-Lin Wu, PhD, M Med, FACMG

Highly Sensitive Test for Acute Appendicitis        

        Keywords: Diagnostic/Prognostic, Gastrointestinal/Nutrition, Inflammation, Biomarker
      Lead Investigator: Alex Kentsis, MD, PhD

Chromosomal Instability Signature Predicts Prognosis in Cancer        

        Keywords: Diagnostic/Prognostic, Oncology/Hematology, Biomarker
      Lead Investigator: Zoltan Szallasi, MD

Devices:

Hydration Monitor        

        Keywords: Neonatology/Pediatric, Medical Device
      Lead Investigator: Vassilios Bezzerides, MD, PhD

*To search the full list of technologies, click [here]

New Issued Patents

Leonard I. Zon  |  US 7,521,055  |  Ferroportin1 Antibodies and Methods

Judah Folkman  |  US 7,524,811  |  Anti-Antigenic Peptides from the N-Terminus of Endostatin

Stephen Harrison  |  US 7,524,624  | Novel Inhibition of Dengue Infection 

Mark Puder  |  US 7,527,123  |  Patient-Friendly Stethoscope

Wayne Lencer  |  US 7,547,436  |  Receptor Specific Transepithelial Transport of Therapeutics

Zhigang He  |  US 7,524,640 |  Inhibiting Smad Signaling Promotes Neuron Regeneration

Atul Butte  |  US 7,576,052 |  Methods and Compositions for Modulating Adipocyte Function

New Scientific Publications

Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009 Jul 23;138(2):257-70. PMID: 19632177

Kang SY, Halvorsen OJ, Gravdal K, Bhattacharya N, Lee JM, Liu NW, Johnston BT, Johnston AB, Haukaas SA, Aamodt K, Yoo S, Akslen LA, Watnick RS. Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1. Proc Natl Acad Sci U S A. 2009 Jul 6. PMID: 19581582

Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature. 2009 Jul 9;460(7252):259-63. Epub 2009 Jun 10. PMID: 19516257

Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R. Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med. 2009 Jun 25. PMID: 19556024

North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15;137(4):736-48. PMID: 19450519

Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7125-30. Epub 2009 Apr 13. PMID: 19365067

CHB Research in the News

Biotech Transfer Week: Children's Hospital Boston Debuts Biomedical Technology Development Fund

TIME: Is a Swine Flu Outbreak Coming? Ask Your iPhone

Reuters: Drug-Dispensing Contact Lens Passes Early Tests

Technology Review: Protein Treatment Repairs Heart Damage

New Scientist: First Heartbeats Trigger Blood Formation